Interleukin-28B polymorphisms and hepatitis C virus clearance
نویسندگان
چکیده
منابع مشابه
Lack of association between interleukin 28B polymorphisms and spontaneous viral clearance in hepatitis B virus patients.
TO THE EDITOR—We read the article by Seto et al [1] with interest. The authors investigated the correlation of HLA-DP and interleukin 28B (IL-28B) polymorphisms with hepatitis B surface antigen (HBsAg) seroclearance in hepatitis B virus (HBV) patients, and found that IL-28B haplotype CG (rs12979860/rs8099917) was associated with HBsAg clearance. The role of IL-28B polymorphisms in HBV has been ...
متن کاملMysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance- A Meta-Analysis
BACKGROUND Recent genome wide association studies (GWAS) have shown important roles of single nucleotide polymorphisms (SNP) near region of interleukin B 28 (IL28B) gene in spontaneous and drug-induced clearance of hepatitis C virus (HCV) in genotype 1 HCV infection. OBJECTIVES This meta-analysis was designed to determine the world-wide distribution patterns of IL28B genotypes and alleles, an...
متن کاملmysterious linkages between hepatitis c virus genotypes, interleukin-28b genotypes and viral clearance- a meta-analysis
conclusions there were significant linkages between hcv genotypes and il28b genotypes/alleles. patients with a favorable il28b and genotypes 1 and 4 hcv infection stand a better chance to clear hcv in the acute phase. objectives this meta-analysis was designed to determine the world-wide distribution patterns of il28b genotypes and alleles, and to find possible linkages between il28b and hcv ge...
متن کاملEstimating the Net Contribution of Interleukin-28B Variation to Spontaneous Hepatitis C Virus Clearance
UNLABELLED The identification of associations between interleukin-28B (IL-28B) variants and the spontaneous clearance of hepatitis C virus (HCV) raises the issues of causality and the net contribution of host genetics to the trait. To estimate more precisely the net effect of IL-28B genetic variation on HCV clearance, we optimized genotyping and compared the host contributions in multiple- and ...
متن کاملRole of Interleukin-28B Genetic Polymorphisms in Korean Patients with Hepatitis C Virus Infection
BACKGROUND/AIMS This study investigated the role of single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B) gene with respect to clinical outcomes and the antiviral response in hepatitis C virus (HCV) infection to suggest the practical utility of IL28B genotyping in Korea. METHODS Two SNPs near IL28B, rs12979860 and rs8099917, were analyzed using an allelic discrimination assa...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2013
ISSN: 1756-994X
DOI: 10.1186/gm410